Thank you, Mario, but our protein is in another configuration!
By Thoreau
University of Washington researchers have developed a computer game that folds proteins. Yes, really.
Protein folding is a tough problem. You’ve got this long chain of amino acids, and somehow they come together to take on a particular shape. And they do this every time a cell produces the protein. You’d think that a long chain of molecules would try all sorts of random configurations, but somehow they always form the same pattern. It’s hard to understand why, because all of the molecules are interacting with each other in very complicated ways, so you have to solve an equation that could involve hundreds or thousands of forces. Some computers are having luck folding a few proteins, but it’s slow.
The researchers theorized that people are very good at playing games and picking out the most efficient way to do something. Good gamers intuitively know which traps to avoid. So they designed a game where you try to fold up a molecule into the most stable shape (the one where the forces all cancel and the energy is at a minimum). They tested it on some proteins with known structures, and they got good results. Now they’re trying proteins with unknown structures.
So to all my students, I say “Go and play more video games! Do something useful for science!”
I predict that we’ll start seeing research article titles like “PWNAGE of Matrix Metalloprotease 9 Structure! SW33T!” by DoneGeneMaster11 et. al.
